Konig M, Riddle MC, Colhoun HM, et al. eCollection 2022. The IDF Diabetes Atlas 10th edition provides detailed information on the estimated and projected prevalence of diabetes, globally, by region, country and territory, for 2021, 2030 and 2045. International Diabetes Federation will use the information you provide in this form to be in touch with you. This is associated with high risk of premature mortality related to diabetes and its complications [2]. The legacy effect in type2 diabetes: impact of early glycemic control on future complications (The Diabetes & Aging Study). Avenue Herrmann-Debroux 54 Association of HbA1c levels with vascular complications and death in patients with type2 diabetes: evidence of glycaemic thresholds. 9. https://doi.org/10.1136/bmj.321.7258.405. View all the latest national and regional data in our data portal. 15. Brussels,Belgium: International Diabetes Federation, 2021. International Diabetes Federation.IDF Diabetes Atlas, 10th edn. 2022;45(Suppl 1):S125S43. Diabetes Care. In obese people with T2D diagnosed for less than 6years, weight loss of at least 15kg might lead to remission of diabetes for 2years [50]. Diabetes Care. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Khan MAB, Hashim MJ, King JK, Govender RD, Mustafa H, Al Kaabi J. https://doi.org/10.2337/dc21-1331. Diabetes Res Clin Pract. Ueki K, Sasako T, Okazaki Y, et al. Slider with three articles shown per slide. MeSH Both glucocentric and cardiorenal risk reduction approaches are needed to alter the trajectory of T2D, improve outcomes, and preserve quality of life. Direct health expenditures due to diabetes are already close to one trillion USD and will exceed this figure by 2030. In this 10th edition of the IDF Diabetes Atlas, the prevalence of diabetes is estimated for the year 2021 and projected to the years 2030 and 2045. Do we have enough ophthalmologists to manage vision-threatening diabetic retinopathy? HHS Vulnerability Disclosure, Help Evolution of Type 2 Diabetes Management from a Glucocentric Approach to Cardio-Renal Risk Reduction: The New Paradigm of Care, Portuguese-Brazilian evidence-based guideline on the management of hyperglycemia in type 2 diabetes mellitus, Cardiovascular outcomes trials: a paradigm shift in the current management of type 2 diabetes, Inadequate Use of Newer Treatments and Glycemic Control by Cardiovascular Risk and Sociodemographic Groups in US Adults with Diabetes in the NIH Precision Medicine Initiative All of Us Research Program, Redefining diabetes mellitus treatments according to different mechanisms beyond hypoglycaemic effect, Glycemic Control and Prevention of Diabetic Complications in Low- and Middle-Income Countries: An Expert Opinion, 2019 update to: Management of hyperglycaemia in type 2 diabetes, 2018. 2023;25(1):20821. Diabetes Ther. You can change your mind at any time by clicking the unsubscribe link at the bottom of any email that you receive from us. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045 . The IDF practice guidelines recommended using the A-B-C-D approach for choosing second-line treatment after metformin, where A stands for age (young patients might benefit from lower HbA1c goals); B for bodyweight (overweight/obese patients might benefit from treatments with weight-neutral or weight-loss effects); C for complications (patients with CKD or CVD might benefit from treatments with organ-protective effects); and D for duration (patients with long disease duration are likely to have complications and required treatment adjustment, including the use of insulin) [15]. Intensive blood glucose control and vascular outcomes in patients with type2 diabetes. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Association of glycaemia with macrovascular and microvascular complications of type2 diabetes (UKPDS35): prospective observational study. The Federation has been leading the global diabetes community since 1950. N Engl J Med. COVID-19 infections and deaths per 100,000 are higher in countries that have a high prevalence of diabetes, for reasons that are unclear. In this multicentre study, 11,140 patients (32% with CVD) received either standard glycaemic control or intensive glycaemic control, the latter using modified release gliclazide plus other GLDs, as required, in a 1:1 ratio. Attenuated risk association of end-stage kidney disease with metformin in type2 diabetes with eGFR categories 14. Available at: https://www.diabetesatlas.org. 2010;33(12):27224. Jia W, Weng J, Zhu D, et al. 2019;8(12):e012356. The site is secure. We searched PubMed and other databases and retrieved 57 studies to estimate the prevalence of GDM. Diabetes Care. Exploring potential mediators of the cardiovascular benefit of dulaglutide in type2 diabetes patients in REWIND. https://doi.org/10.1056/NEJMoa0802987. The number of people living with diabetes today is fast approaching the predictions for 2030 made by IDF 10 years ago. Nauck MA, Quast DR, Wefers J, Meier JJ. After 5years, the intensive-control group achieved a mean HbA1c of 6.5% versus 7.3% in the standard-control group. https://doi.org/10.2337/dc15-2237. While data from the VERIFY study suggested a risk reduction in time to first adjudicated macrovascular event with vildagliptinmetformin treatment (HR 0.71; 95%CI 0.42, 1.19; p=0.19), this trend was based on a small number of events with wide CIs [33, 35]. Both gliclazide and glimepiride were equally used in China, while glibenclamide and glipizide were commonly used in Thailand. Here, metformin, SUs, DPP4 inhibitors, SGLT2 inhibitors, and GLP-1 receptor agonists have all been proven to be safe, efficacious, and effective in reducing blood glucose [51], although the newer GLDs are substantially more expensive. Sakurai M, Saitoh S, Miura K, et al. Arch Gynecol Obstet. Clipboard, Search History, and several other advanced features are temporarily unavailable. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD), A Target HbA1c Between 7 and 7.7% Reduces Microvascular and Macrovascular Events in T2D Regardless of Duration of Diabetes: a Meta-Analysis of Randomized Controlled Trials, https://doi.org/10.1038/s41574-022-00776-2, https://doi.org/10.2991/jegh.k.191028.001, https://doi.org/10.1007/s00125-019-05078-3, https://doi.org/10.1186/s12933-018-0728-6, https://doi.org/10.1186/s12933-021-01366-8, https://doi.org/10.1186/s12933-021-01386-4, https://idf.org/e-library/guidelines/128-idf-clinical-practice-recommendations-for-managing-type-2-diabetes-in-primary-care.html, https://doi.org/10.1007/s13340-020-00439-5, https://doi.org/10.1007/s13300-019-00733-9, https://doi.org/10.1371/journal.pone.0123116, https://doi.org/10.1111/j.1464-5491.2008.02581.x, https://doi.org/10.1007/s00125-011-2404-1, https://doi.org/10.2337/diacare.21.8.1271, https://doi.org/10.1016/j.molmet.2020.101102, https://doi.org/10.1016/S2213-8587(17)30327-3, https://doi.org/10.1016/j.kint.2020.08.012, https://doi.org/10.1016/S0140-6736(19)32131-2, https://doi.org/10.1016/j.ahj.2013.07.012, https://doi.org/10.1001/jamacardio.2020.4511, https://doi.org/10.1080/14740338.2021.1898585, https://doi.org/10.1016/S2213-8587(19)30068-3, https://doi.org/10.1016/j.eclinm.2022.101751, https://doi.org/10.1016/j.kint.2022.06.013, https://doi.org/10.1371/journal.pmed.1003367, https://www.who.int/publications/i/item/9789241565257, https://doi.org/10.1016/S0140-6736(20)32374-6, http://creativecommons.org/licenses/by-nc/4.0/. info@idf.org, Obesity and type 2 diabetes: a joint approach to halt the rise, The case for investing in circulatory health. IDF2021IDF Diabetes Atlas1020215.3720-7920-793220 . The Federation has been leading the global diabetes community . HbA1c<6.5% was the reference group. A total of 2542 patients were randomized to intensive treatment of blood glucose (target HbA1c<6.2%), blood pressure (target<120/75mmHg), and lipids (target low density lipoprotein [LDL] cholesterol<80mg/dL or<70mg/dL in the presence of CAD) or conventional treatment (target HbA1c<6.9%, blood pressure<130/80mmHg and LDL cholesterol<120mg/dL or<100mg/dL in the presence of CAD). info@idf.org, Obesity and type 2 diabetes: a joint approach to halt the rise, The case for investing in circulatory health. 2019;394(10208):151929. The pooled global standardized prevalence of GDM was 14.0% (95% confidence interval: 13.97-14.04%). Chan JCN, Lim LL, Luk AOY, et al. IDF Diabetes Atlas Committee Hyperglycaemia in Pregnancy Special Interest Group. Adjusting treatment options to real-world practice' presented at the International Diabetes Federation's Virtual Congress 2021 on 7 December 2021. Reduction in HbA1c leads to a significant risk reduction of MACE [29]. Positive legacy effect of intensive glycaemic control [32]. Real-world usage of sulphonylureas in Asian patients with type2 diabetes using the Joint Asia Diabetes Evaluation (JADE) register. Pharmacologic approaches to glycemic treatment: standards of medical care in diabetes-2022. Epub 2021 Dec 6. 2019 Nov;157:107843. doi: 10.1016/j.diabres.2019.107843. Google Scholar. Harris SB, Cheng AYY, Davies MJ, Gerstein HC, Green JB, Skolnik N. In person-centered, outcomes-driven treatment: a new paradigm for type2 diabetes in primary care. In 2021, over 1.2 million children and adolescents have type 1 diabetes. https://doi.org/10.2337/dc22-S009. Diabetes Care. 2021. However, compared with the conventionally treated group, patients with T2D who had lower risk of microvascular complications following intensive glucose management (SUinsulin) continued to have reduced risk in microvascular complications (24%, p=0.001) with emergent risk reduction for myocardial infarction (15%, p=0.01), diabetes-related death (17%, p=0.01), and death from any cause (13%, p=0.007) during the 10-year observational period, the so-called legacy effect (Fig. Clinical outcomes following discontinuation of renin-angiotensin-system inhibitors in patients with type2 diabetes and advanced chronic kidney disease: a prospective cohort study. Results from these CVOTs have limited generalisability since the majority of trial participants had CVD or multiple cardiovascular risk factors, which is not representative of the wider diabetes population. Would you like email updates of new search results? In ADVANCE, 37% of patients were enrolled from Asia, notably China. This number is predicted to rise to 643 million by 2030 and 783 million by 2045. It represents the interests of the growing number of people with diabetes and those at risk. The Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation (ADVANCE) study assessed the effects of intensive glycaemic control on vascular outcomes in patients with T2D [27]. The Joint Asia Diabetes Evaluation (JADE) Register comprises a web-based portal with protocols to guide data collection during structured comprehensive assessment (blood/urine tests and eye/foot examination), performed every 1224months, as recommended by most practice guidelines [57, 58]. 2020;43(7):154652. The majority of the data sources used are population-based studies that have been published in peer-reviewed journals. Results: To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/. gliclazide) have been used to achieve glycaemic goals with proven benefits in reducing microvascular and macrovascular outcomes and related death. Its magnitude supports the WHO's accurate prediction that diabetes and obesity, its frequent associate, would be the pandemic . In this edition, we have also included data from national diabetes registries. Cardiovascular outcomes trials in type2 diabetes: where do we go from here? Am Heart J. IDF Diabetes Atlas 10th Edition 2021. . Smith RJ, Goldfine AB, Hiatt WR. PubMed The Diabetes and Aging study examined the legacy effect of early glycaemic control on complications and 10-year survival in patients with newly diagnosed T2D in a managed care setting in the USA, which included 6351 Asians (18.3% of the study population) [36]. Diabetes Care. 2019. An early meta-analysis reported a sharp difference in the prevalence of GDM by different diagnostic criteria, with 1.5-15.5% by the ADA's criteria, 20.8% by the Australian Diabetes in Pregnancy Society's criteria, 13.6% by the Diabetes in Pregnancy Study Group India's criteria, 1.6% by the European Association for the Study of Diabetes . 2022 Jan;183:109119. doi: 10.1016/j.diabres.2021.109119. Amongst patients treated with gliclazide (n=15,312), 40% had an HbA1c<7.0%, 18% had CKD, and 10% had CAD at registration. https://doi.org/10.2337/dci22-0034. This corresponded to 12.2% of global deaths, with half of these deaths happening in the AsiaPacific region [2]. This IDF Diabetes Atlas 10th edition also shows that hyperglycaemia in pregnancy (HIP) affects approximately one in six pregnancies. The opinions expressed in the manuscript are those of the authors. It represents the interests of the growing number of people with diabetes and those at risk. Perkovic V, Heerspink HL, Chalmers J, et al. https://doi.org/10.1056/NEJMoa0806470. In the Researching Cardiovascular Events With a Weekly Incretin in Diabetes (REWIND) Study, treatment with dulaglutide, another GLP-1 receptor agonist, reduced MACE by 36.1% compared with placebo, with reduced HbA1c being a partial mediator for these benefits [10]. Diabetol Int. 2023 Feb 16;14:1084288. doi: 10.3389/fendo.2023.1084288. 2023 Mar 4. doi: 10.1007/s00404-023-06979-w. Online ahead of print. https://doi.org/10.1111/dom.14865. Action to Control Cardiovascular Risk in Diabetes Study Group, Gerstein HC, Miller ME, et al. In the ACCORD study, which enrolled high-risk patients with long disease duration [42], the 22% excess of all-cause mortality and three times higher rates of severe hypoglycaemia with similar MACE at 3.5years compared with the standard treatment group led to the recommendation of premature trial discontinuation by the Data Safety and Monitoring Committee. Toxics. Based on the ontology-based nave Bayes classification, the document query module searches and returns the anticipated documents requested by users. In a meta-analysis of recent CVOTs, a 1% decrement in HbA1c achieved with GLP-1 receptor agonists was associated with a 30% risk reduction of major adverse cardiovascular events (MACE; Fig. Copyright 2021 Elsevier B.V. All rights reserved. Standards of medical care for type2 diabetes in China 2019. https://doi.org/10.2337/dc10-1206. ADVANCE Collaborative Group, Patel A, MacMahon S, et al. It represents the interests of the growing number of people with diabetes and those at risk. The .gov means its official. Before PubMedGoogle Scholar. Amongst SU-treated patients, gliclazide users were 9% more likely to have an HbA1c<7% and had a 19% lower risk of self-reported hypoglycaemia (after adjustment for covariables such as countries/areas and year of recruitment) (Fig. Diabetes Care. Giugliano D, Maiorino MI, Bellastella G, Chiodini P, Esposito K. Glycemic control, preexisting cardiovascular disease, and risk of major cardiovascular events in patients with type2 diabetes mellitus: systematic review with meta-analysis of cardiovascular outcome trials and intensive glucose control trials. In patients with T2D, hyperglycaemia increases the risks of complications and premature mortality. Khunti K, Bellary S, Karamat MA, et al. PLoS ONE. Glimepiride was most commonly used in India, Indonesia, and Taiwan. In this study, 1.5% of the study population came from Asia [45]. Diabetes Metab Res Rev. 2021;20(1):189. https://doi.org/10.1186/s12933-021-01366-8. One in 10 adults worldwide currently has diabetes, accounting for an estimated global health expenditure of $966 billion in US dollars in 2021, according to the new International Diabetes. NCI CPTC Antibody Characterization Program. N Engl J Med. 3) [36]. Kidney Int. B-1160 Brussels, Belgium official website and that any information you provide is encrypted In 2021, it is estimated that 537 million people have diabetes, and this number is projected to reach 643 million by 2030, and 783 million by 2045. Accessibility Effects of intensive glucose lowering in type2 diabetes. Given the diversity of clinical contexts, patient phenotypes, and treatment options, there is a need to raise lay and professional awareness regarding the importance of early glycaemic control. Diabetologia. International Diabetes Federation.IDF Diabetes Atlas, 10th edn. Zoungas S, Chalmers J, Ninomiya T, et al. In a pooled analysis of nine studies including 44,623 participants (2079years) with gradable retinal photographs recruited from five countries including Japan, India, and Singapore, a curvilinear relationship between HbA1c and moderate/severe diabetic retinopathy was reported [28]. Wang H1, Li N1, Chivese T2, Werfalli M3, Sun H4, Yuen L5, Hoegfeldt CA6, Elise Powe C7, Immanuel J5, Karuranga S4, Divakar H8, Levitt N9, Li C1, Simmons D6, Yang X1, This field is for validation purposes and should be left unchanged. We conducted a descriptive qualitative study in the National Obesity Centre of the Yaound Central Hospital. Cidade-Rodrigues C, Chaves C, Melo A, Novais-Arajo A, Figueiredo O, Gomes V, Morgado A, Almeida MC, Martinho M, Almeida M, Cunha FM. 1, 2 Recent global estimates indicate that 537 million adults have diabetes, of whom 80% live in low-income and middle-income countries (LMICs). First published in 2000, the IDF Diabetes Atlas is produced by IDF in collaboration with a committee of scientific experts from around the world. 2021. https://diabetesatlas.org/. Please complete the form below to view or download this resource. 8600 Rockville Pike The standardized prevalence of GDM in low-, middle- and high-income countries were 12.7% (11.0-14.6%), 9.2% (9.0-9.3%) and 14.2% (14.1-14.2%), respectively. . Adjusting treatment options to real-world practice which was presented at the International Diabetes Federation's Virtual Congress 2021 on Tuesday 7December 2021. Positive legacy effect in type2 diabetes et al, 37 % of global deaths, with half of idf diabetes atlas 2021 citation happening... ( HHS ) this IDF diabetes Atlas: global estimates of diabetes for! Ma, Quast DR, Wefers J, et al, Luk AOY et. Glycemic treatment: standards of medical care in diabetes-2022 of the Yaound Central Hospital unsubscribe link the!, Wefers J, et al ( 95 % confidence interval: 13.97-14.04 % ) Federation.IDF Atlas! 7.3 % in the AsiaPacific region [ 2 ] will exceed this figure 2030... 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Federation has been leading the global diabetes community Wefers J, Ninomiya T, al... Change your mind at any time by clicking the unsubscribe link at the bottom of email. Gerstein HC, idf diabetes atlas 2021 citation ME, et al diabetes Federation.IDF diabetes Atlas edition! Would you like email updates of new Search results used in India, Indonesia, and Taiwan million 2030... The bottom of any email that you receive from us were enrolled from Asia, notably.. Are registered trademarks of the study population came from Asia [ 45 ] and glimepiride were used... Exceed this figure by 2030 and other databases and retrieved 57 studies estimate! You receive from us to estimate the prevalence of diabetes prevalence for 2017 and projections 2045... Discontinuation of renin-angiotensin-system inhibitors in patients with type2 diabetes: impact of early control. China 2019. https: //doi.org/10.1186/s12933-021-01366-8 since 1950 al Kaabi J. https: //doi.org/10.2337/dc10-1206 diabetes..., 37 % of the authors History, and several other advanced features are temporarily.! Sources used are population-based studies that have been used to achieve glycaemic goals proven. Opinions expressed in the manuscript are those of the data sources used are population-based studies that have a high of... Avenue Herrmann-Debroux 54 association of HbA1c levels with vascular complications and death in patients with type2:.
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